Publications

Carlos A Elena-Real, Annika Urbanek, Xamuel L Lund, Anna Morató, Amin Sagar, Aurélie Fournet, Alejandro Estaña, Tracy Bellande, Frédéric Allemand, Juan Cortés, Nathalie Sibille, Ronald Melki, Pau Bernadó. Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1. Structure, 10.1016/j.str.2023.04.003.

Javier González-Delgado, Amin Sagar, Christophe Zanon, Kresten Lindorff-Larsen, Pau Bernadó, Pierre Neuvial, Juan Cortés. WASCO: A Wasserstein-based Statistical Tool to Compare Conformational Ensembles of Intrinsically Disordered Proteins. J Mol Biol 2023, 10.1016/j.jmb.2023.168053.

Cheerneni S. Srinivas, Gayathri S. Singaraju, Veerpal Kaur, Sayan Das, Sanat K. Ghosh, Amin Sagar, Anuj Kumar, Tripta Bhatia & Sabyasachi Rakshit. Transient interactions drive the lateral clustering of cadherin-23 on membrane. Communications Biology 2023, https://doi.org/10.1038/s42003-023-04677-6.

Carlos A Elena-Real, Amin Sagar, Annika Urbanek, Matija Popovic, Anna Morató, Alejandro Estaña, Aurélie Fournet, Christine Doucet, Xamuel L Lund, Zhen-Dan Shi, Luca Costa, Aurélien Thureau, Frédéric Allemand, Rolf E Swenson, Pierre-Emmanuel Milhiet, Ramon Crehuet, Alessandro Barducci, Juan Cortés, Davy Sinnaeve, Nathalie Sibille, Pau Bernadó. The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity. Nature Structure and Molecular Biology 2023, 10.1038/s41594-023-00920-0.

Myriam Guillien, Assia Mouhand, Amin Sagar, Aurélie Fournet, Frédéric Allemand, Glaécia A. N. Pereira, Aurélien Thureau, Pau Bernadó, Jean-Louis Banères, Nathalie Sibille. Phosphorylation motif dictates GPCR C-terminal domain conformation and arrestin interaction. Structure 2023, 10.1016/j.str.2023.08.011.

Bertorelle, F.; Wegner, D.; Bakulić, M. P.; Fakhouri, H.; Comby-Zerbino, C.; Sagar, A.; Bernadó, P.; Resch-Genger, U.; Koutecky, V. B.; Guével, X. Le; Antoine, R. Conformational buffering underlies functional selection in intrinsically disordered protein regions. Nature structural & molecular biology 2022, 10.1038/s41594-022-00811-w.

Bertorelle, F.; Wegner, D.; Bakulić, M. P.; Fakhouri, H.; Comby-Zerbino, C.; Sagar, A.; Bernadó, P.; Resch-Genger, U.; Koutecky, V. B.; Guével, X. Le; Antoine, R. Tailoring NIR-II Photoluminescence of Single Thiolated Au25 Nanoclusters by Selective Binding to Proteins. Chemistry – A European Journal 2022, 10.1002/chem.202201878.

Iruela, G.; Fernández, A.; Sagar, A.; Carvajal, F. J.; Bernadó, P; Pons, M. A FRET-Based Biosensor for the Src N-Terminal Regulatory Element. Biosensors 2022, 12 (2), 10.3390/bios12020096.

Sagar, A.; Herranz-Trillo, F.; Langkilde, A. E.; Vestergaard, B.; Bernadó, P. Structure and Thermodynamics of Transient Protein-Protein Complexes by Chemometric Decomposition of SAXS Datasets. Structure 2021, 29 (9), 1074-1090.e4. https://doi.org/10.1016/j.str.2021.03.017. Co-Corresponding Author

del Amo-Maestro, L.; Sagar, A.; Pompach, P.; Goulas, T.; Scavenius, C.; Ferrero, D. S.; Castrillo-Briceño, M.; Taulés, M.; Enghild, J. J.; Bernadó, P.; Gomis-Rüth, F. X. An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution. J. Mol. Biol. 2021. https://doi.org/10.1016/j.jmb.2021.166954.

Sagar, A.; Jeffries, C. M.; Petoukhov, M. V.; Svergun, D. I.; Bernadó, P. Comment on the Optimal Parameters to Derive Intrinsically Disordered Protein Conformational Ensembles from Small-Angle X-Ray Scattering Data Using the Ensemble Optimization Method. J. Chem. Theory Comput. 2021. https://doi.org/10.1021/acs.jctc.1c00014.

Joshi, T.; Garg, S.; Estaña, A.; Cortés, J.; Bernadó, P.; Das, S.; Kammath, A. R.; Sagar, A.; Rakshit, S. Interdomain Linkers Tailor the Stability of Immunoglobulin Repeats in Polyproteins. Biochem. Biophys. Res. Commun. 2021. https://doi.org/10.1016/j.bbrc.2021.02.114. (Corresponding Author)

Clerc, I.; Sagar, A.; Barducci, A.; Sibille, N.; Bernadó, P.; Cortés, J. The Diversity of Molecular Interactions Involving Intrinsically Disordered Proteins: A Molecular Modeling Perspective. Comput. Struct. Biotechnol. J. 2021. https://doi.org/10.1016/j.csbj.2021.06.031.

Garg, S.; Sagar, A.; Singaraju, G. S.; Dani, R.; Bari, N. K.; Naganathan, A. N.; Rakshit, S. Weakening of Interaction Networks with Aging in Tip-Link Protein Induces Hearing Loss. Biochem. J. 2021.https://doi.org/10.1042/BCJ20200799. (Co-First)

Kaur, N.; Sagar, A.; Sharma, P.; Ashish; Pati, P. K. Structural Insights into Rice SalTol QTL Located SALT Protein. Sci. Rep. 2020. https://doi.org/10.1038/s41598-020-73517-y. (Co-First)

Singaraju, G. S.; Sagar, A.; Kumar, A.; Samuel, J. S.; Hazra, J. P.; Sannigrahi, M. K.; Yennamalli, R. M.; Ashish, R. M.; Rakshit, S. Structural Basis of the Strong Cell-Cell Junction Formed by Cadherin-23. FEBS J. 2020. https://doi.org/10.1111/febs.15141.

Sagar, A.; Svergun, D.; Bernadó, P. Structural Analyses of Intrinsically Disordered Proteins by Small-Angle X-Ray Scattering. In Methods in Molecular Biology; 2020. https://doi.org/10.1007/978-1-0716-0524-0_12.

Kumar, V.; Peter, J. J.; Sagar, A.; Ray, A.; Jha, M. P.; Rebeaud, M. E.; Tiwari, S.; Goloubinoff, P.; Ashish; Mapa, K. Interdomain Communication Suppressing High Intrinsic ATPase Activity of Sse1 Is Essential for Its Co-Disaggregase Activity with Ssa1. FEBS J. 2020. https://doi.org/10.1111/febs.15045.

Vaid, B.; Chopra, B. S.; Raut, S.; Sagar, A.; Badmalia, M. D.; Ashish; Khatri, N. Antioxidant and Wound Healing Property of Gelsolin in 3T3-L1 Cells. Oxid. Med. Cell. Longev. 2020. https://doi.org/10.1155/2020/4045365.

Hazra, J. P.; Sagar, A.; Arora, N.; Deb, D.; Kaur, S.; Rakshit, S. Broken Force Dispersal Network in Tip-Links by the Mutations at the Ca2+-Binding Residues Induces Hearing-Loss. Biochem. J. 2019. https://doi.org/10.1042/BCJ20190453.

Gupta, A. K.; Chopra, B. S.; Vaid, B.; Sagar, A.; Raut, S.; Badmalia, M. D.; Ashish; Khatri, N. Protective Effects of Gelsolin in Acute Pulmonary Thromboembolism and Thrombosis in the Carotid Artery of Mice. PLoS One 2019. https://doi.org/10.1371/journal.pone.0215717.

Hazra, J. P.; Arora, N.; Sagar, A.; Srinivasan, S.; Chaudhuri, A.; Rakshit, S. Force-Activated Catalytic Pathway Accelerates Bacterial Adhesion against Flow. Biochem. J. 2018. https://doi.org/10.1042/BCJ20180358.

Sagar, A.; Arif, E.; Solanki, A. K.; Srivastava, P.; Janech, M. G.; Kim, S. H.; Lipschutz, J. H.; Kwon, S. H.; Ashish; Nihalani, D. Targeting Neph1 and ZO-1 Protein-Protein Interaction in Podocytes Prevents Podocyte Injury and Preserves Glomerular Filtration Function. Sci. Rep. 2017. https://doi.org/10.1038/s41598-017-12134-8.

Sagar, A.; Haleem, N.; Bashir, Y. M.; Ashish. Search for Non-Lactam Inhibitors of Mtb β-Lactamase Led to Its Open Shape in Apo State: New Concept for Antibiotic Design. Sci. Rep. 2017. https://doi.org/10.1038/s41598-017-06023-3.

Gupta, A. K.; Parasar, D.; Sagar, A.; Choudhary, V.; Chopra, B. S.; Garg, R.; Ashish; Khatri, N. Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. PLoS One 2015, 10 (8), e0135558. https://doi.org/10.1371/journal.pone.0135558. (Co-Corresponding Author)

Rehan, M.; Sagar, A.; Sharma, V.; Mishra, S.; Ashish; Sahni, G. Penta-l-Lysine Potentiates Fibrin-Independent Activity of Human Tissue Plasminogen Activator. J. Phys. Chem. B 2015. https://doi.org/10.1021/acs.jpcb.5b07735

Rathore, Y. S.; Dhoke, R. R.; Badmalia, M.; Sagar, A.; Ashish. SAXS Data Based Global Shape Analysis of Trigger Factor (TF) Proteins from E. Coli, V. Cholerae, and P. Frigidicola: Resolving the Debate on the Nature of Monomeric and Dimeric Forms. J. Phys. Chem. B 2015. https://doi.org/10.1021/acs.jpcb.5b00759.

Khatri, N.; Sagar, A.; Peddada, N.; Choudhary, V.; Chopra, B. S.; Garg, V.; Garg, R.; Ashish. Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin. J. Diabetes Res. 2014. https://doi.org/10.1155/2014/152075.

Singh, S.; Pandey, K.; Rathore, Y. S.; Sagar, A.; Pattnaik, U. B. K.; Ashish, G. A Communication Network within the Cytoplasmic Domain of Toll-like Receptors Has Remained Conserved during Evolution. J. Biomol. Struct. Dyn. 2014. https://doi.org/10.1080/07391102.2013.787545.

Peddada, N.; Sagar, A.; Ashish; Garg, R. Plasma Gelsolin: A General Prognostic Marker of Health. Med. Hypotheses 2012, 78 (2), 203–210. https://doi.org/10.1016/j.mehy.2011.10.024.

Sagar, A.; Peddada, N.; Solanki, A. k.; Choudhary, V.; Garg, R.; Ashish. Visualizing the Elusive Open Shape of G-Actin in Solution by SAXS Data Analysis. Biochem. Biophys. Res. Commun. 2013. https://doi.org/10.1016/j.bbrc.2013.05.055.

Garg, R.; Peddada, N.; Sagar, A.; Nihalani, D.; Ashish. Visual Insight into How Low PH Alone Can Induce Actin-Severing Ability in Gelsolin under Calcium-Free Conditions. J. Biol. Chem. 2011. https://doi.org/10.1074/jbc.M111.236943.